QUANTIFOIL® Holey Carbon Film supports with circular holes are used in a wide range of applications from materials science to molecular biology and biomedical imaging. The circular holes allow improved sample distribution and reduced background scatter due to the formation of thin, even layers of vitrified ice that support the particles of interest. Users can select from a wide range of holes depending on their sample characteristics and imaging modality:
A Mix Box of 30 grids in popular sizes (QUANTIFOIL® R 1.2/1.3, R 2/1, R 3.5/1, S 7/2, Multi A and continuous Carbon) on Copper 300 mesh base grids is available to help select the optimum foil.
Our Carbon support films can be supplied on a number alternative meshes and finder grid formats for integrated methods and other applications.
As a rough guide:
A larger sample size will require larger hole sizes. For example:
The table below provides a list of QUANTIFOIL® circular hole geometries, which can be ordered direct from us or via our network of distributors.
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QUANTIFOIL® geometry
Hole size (μm)*
Spacing (µm)*
Periodicity (µm)*
R 0.6/1
0.6
1.0
1.6
R 1/1
1.0
1.0
2.0
R 1/2
1.0
2.0
3.0
R 1/4
1.0
4.0
5.0
R 1.2/1.3
1.2
1.3
2.5
R 1.2/20
1.2
20.0
21.2
R 2/1
2.0
1.0
3.0
R 2/2
2.0
2.0
4.0
R 2/4
2.0
4.0
6.0
R 3/3
3.0
3.0
6.0
R 3/5
3.0
5.0
8.0
R 3.5/1
3.5
1.0
4.5
R 5/2
5.0
2.0
7.0
R 5/20
5.0
20.0
25.0
R 6/6.5
6.0
6.5
12.5
R 8/3
8.0
3.0
11.0
R 10/5
10.0
5.0
15.0
R 10/10
10.0
10.0
20.0
R 10/20
10.0
20.0
30.0
R 17/5
17.0
5.0
22.0
Improve particle density and dispersion by adding an ultrathin continuous carbon layer to most Quantifoil film supports.