A single grid with a range of hole geometries is useful when carrying out cryo-electron tomography (cryo-ET) or where the sample size may vary unpredictably (for example liposomes).The predefined pattern of hole sizes and shapes in QUANTIFOIL® Multi A offers this possibility while still enabling automated data collection, in contrast to the random arrangements of traditional holey or lacey supports.
We can offer Multi A on finder grids and alternative meshes to maximise their utility for tomography and integrated methods applications.
Uses of the Multi A format include:
Koh et al. The structure of a 15-stranded actin-like filament from Clostridium botulinum. Nat. Commun. 10: 2856 (2019)
Rez et al. Damage-free vibrational spectroscopy of biological materials in the electron microscope. Nat. Commun. 7:10945 (2016)